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Istradefylline 40 mg/working day elevated peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/working day. Consider dose reduction of sensitive CYP3A4 substrates.etravirine will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer cle